Before the ink even had time to dry, the state of Virginia filed suit to challenge the health care reform bill as unconstitutional. And I think they'll succeed on both the merits and the politics.
To be clear: I'm a strong supporter of health care reform. The current system is badly b0rken and absolutely needs to be fixed. But forcing people to buy insurance -- or any other product made by a private company -- is pretty clearly (to my unschooled eye) not one of the federal government's enumerated powers. So the current health care reform bill should be overturned on the legal merits. Of course, the legal merits seem to have precious little to do with how the Supreme Court actually rules nowadays. But the politics also auger in favor of overturning. The current Court lists heavily to towards the right, and the cynical part of me is convinced that John Roberts in particular is eagerly awaiting the opportunity to stick it to Obama after the State of the Union flap.
I wish things were otherwise, but I gotta call 'em as I sees 'em.
[UPDATE:] It has been pointed out to me (and I actually knew this but spaced on it when I was writing this post) that the bill doesn't really force you to buy insurance, it just taxes you if you don't. This makes it part of a long tradition of the government coercing people to behave in certain ways through the tax code that have passed constitutional muster. So when I wrote "the current health care reform bill should be overturned on the legal merits" that was my own personal opinion. (Some days I'm a liberal, other days I'm a libertarian.) That is how I think things should be. It is clearly not how they are.
Notwithstanding that there are ample precedents for the government to coerce behavior through the tax code, I still predict that the Court will overturn. This prediction is based purely on my cynical belief that the Court is politicized, and if the Right can muster any reasonable arguments that the law should be overturned (and I think they can) the SC will tend to view those arguments favorably. I could be wrong. I hope I'm wrong. Time will tell.